The association between sense of coherence and quality of life: a cross-sectional study in a sample of patients on hemodialysis

Background Patients on hemodialysis universally experience detriments in their general quality of life (QOL). Sense of coherence (SOC) is a long-standing factor that affects QOL. Nevertheless, the association between SOC and QOL in patients on hemodialysis was seldom investigated. Our research aims to study this association in a sample of Lebanese adult patients on hemodialysis. Methods In this cross-sectional study, SOC was measured using the short version of the “Orientation of Life" scale (SOC-13). QOL was assessed using the Kidney Disease Quality of Life- Short Form (KDQOL-SF). The association between SOC and QOL and its submodalities was first explored using Pearson Correlation and multivariate linear regression analyses, controlling for sociodemographic variables and medical variables. Results 157 patients on hemodialysis (mean(SD) age: 62.1(13.81) years; 58.6% males) were included. Mean QOL score was 51.65 and that of SOC was 48.06. SOC was strongly corrected with the total QOL (r = 0.832; p value < 0.001), as well as its physical functioning (r = 0.767; p value < 0.001), emotional functioning (r = 0.757; p value < 0.001), cognitive functioning (r = 0.740; p value < 0.001), and social functioning (r = 0.773; p value < 0.001) submodailties. SOC was moderately correlated with professional functioning submodality of QOL (r = 0.618; p value < 0.001), but not correlated with the satisfaction with the quality of care (r = 0.052; p = 0.520). Within the regression models accounting for sociodemographic and medical variables, SOC was significantly associated with the total QOL (unstandardized B = 0.803; 95% CI 0.714, 0.893), physical functioning (unstandardized B = 0.761; standardized B = 0.763; 95% CI 0.661, 0.861), emotional functioning (unstandardized B = 1.205; standardized B = 0.757; 95% CI 1.037, 1.372), professional functioning (unstandardized B = 1.142; standardized B = 0.498; 95% CI 0.843, 1.442), cognitive functioning (unstandardized B = 1.239; standardized B = 0.739; 95% CI 1.058, 1.420), and social functioning (unstandardized B = 0.912; standardized B = 0.768; 95% CI 0.790, 1.034). Conclusions In a sample of adult patients on hemodialysis, SOC was positively significantly associated with QOL and its submodalities, expect the satisfaction with the quality of care. The confirmation of the general hypothesis that relates the SOC with the QOL encourages more salutogenic research among this patient population.


Introduction
End-stage kidney disease is a prevalent condition, with more than 2 million people receiving treatment worldwide [1]. Patients on hemodialysis experience substantial financial, professional, physical, and psychosocial hardships [2,3], resulting in detriments in their general quality of life (QOL). The latter refers to one's perceptions regarding their goals, expectations, standards, and concerns, as well as the position they hold in life within the cultural and value systems' context in which they live. QOL is complexly influenced by one's physical and psychological states, independence level, social relationships, and relationship with the salient characteristics of their environment [4]. It is generally believed that the QOL of patients on hemodialysis is poorer than that of age-matched subjects from the general population [5] and to that of patients receiving other forms of renal replacement therapy, especially renal transplantation [6].
QOL is increasingly being recognized as an outcome measure in the evaluation of dialysis therapy [7][8][9], whereby the aim is not only to improve survival, rather enhance the adjustment of patients to physical limitations, lifestyle changes, and medical interventions [10]. Improved QOL in patients on hemodialysis relates to positive outcomes, including decreased hospitalization and mortality [9,11,12]. Hence, the search for factors associated with improved QOL, i.e. salutogenesis, is gaining ground in the scientific literature.
Sense of coherence (SOC) is a long-standing factor that affects QOL. It is a global orientation to perceive the world and the individual environment as understandable, manageable, and meaningful [13]. SOC is a salutogenic concept created by Antonovsky to explain the cause of interindividual differences concerning successful adaptation following stress [14]. Comprehensibility is a person's ability to create a structured representation of a situation that can be chaotic and to know the role a person has in resolving that situation [15]. The second behavioral component, i.e. manageability, comes to give the individual the ability to feel capable of change and to perceive the availability of the necessary resources, general or specific, to escape or face a specific situation [15]. The last component is the motivational component, i.e., meaningfulness. It gives motivation and a reason for overcoming issues that are seen as challenges, and helps to find the desire and the urge to invest energy to overcome a stressful experience [16]. Conceptually, chronic patients with a better comprehension are actively engaged in a cooperative relationship with the healthcare team. Moreover, patients with a better management can better identify and manage resources with optimism and perceive social support. Finally, patients who can find meaning to their disease are more motivated to pursue treatment [17]. Cross-sectional and longitudinal epidemiological data in patients with various diseases, like those with heart disease, cancer, and multiple sclerosis, as well as patients with kidney disease, such as those treated with home dialysis [18,19], indicate that a stronger SOC relates to lower disease burden [20], survival quality [21][22][23][24], and a better perceived QOL [13].
Nevertheless, the independent association between SOC and QOL in patients on hemodialysis was seldom investigated; previous efforts mainly focused on patients in pre-dialysis [25], or those receiving peritoneal dialysis [26], in general through correlational studies. Exploring this association is expected to generate knowledge with implications for clinical practice, particularly therapeutic interventions to enhance SOC, ultimately leading to improve QOL.
The present study aims to assess the relationship between the SOC and the QOL in a sample of patients on hemodialysis in Lebanon. We hypothesize that a high SOC is associated with a better QOL.

Study design
This was a cross-sectional study, conducted between November 2018 and February 2019, in three hospitalbased hemodialysis units in the Mount Lebanon (n = 2) and North (n = 1) Governorates in Lebanon.

Participants
The sample consisted of Lebanese, adult patients, receiving thrice-weekly hemodialysis treatment in three hospital-based units. All eligible patients receiving hemodialysis treatment in these units were approached to participate in the study. Patients receiving dialysis for acute kidney injury without chronic kidney disease, or those who are unconscious, suffering from dementia, under strong medication, i.e. high doses of psychotropic medications inducing sedative effects, or any condition that disable them from responding consciously to the questions, and those who have hearing problems were excluded.

Sample size
Sample size calculation was conducted a priori on GPower 3.1. Using a medium effect size of 0.3, a twotailed significance level at 0.01, and a power of 80%, the required sample size was 122. The chosen effect size was based on the reported correlation coefficient (r) between SOC and the mental component of QOL (r = 0.46) [27] in patients with chronic illness (end-stage renal disease, chronic heart failure, multiple sclerosis, stroke, and Parkinson), and that between SOC to QOL (r = 0.303) [28]. As per Cohen [29], an interval of (r) between 0.3 and 0.5 denotes a medium effect size. The initial sample size was increased by 42% to account for non-response, based on the response rate reported in a similar study (58%) [30], leading to a total of 174 patients.

Outcome measures and assessment tools
Collected information included self-reported sociodemographic data (age, sex, level of education: uneducated, primary and elementary education, secondary education, and higher education), employment status: unemployed/retired, and employed, and marital status: single, married, and divorced/widowed), in addition to dialysisrelated information (cause of kidney failure, duration on hemodialysis: 0-11 months, ≥ 12 months, the latter as a suggested time required for the patient to overcome the trauma of dialysis initiation and to psychologically adjust to dialysis [31], and previous transplants, when applicable), and medical data (use of psychiatric and non-psychiatric medications, number of hospitalization days in the last 6 months, and number of outpatient visits in the last 6 months), which were retrieved from the patients' medical charts. SOC was measured using the "Orientation of Life" scale developed by Antonovsky [16]. The short version of the scale containing 13 items (SOC-13) was used since it is recommended in settings such as hospitals and healthcare centers where it is difficult to use longer versions [32]. The SOC-13 has a well-established face validity, construct validity, consensual validity, and criterion validity in assessing SOC construct [13,17], with good internal consistency (Cronbach's alpha coefficient = 0.70 to 0.92) [13]. SOC-13 includes 5 items for comprehensibility, 4 for manageability, and 4 for meaningfulness. The SOC-13 is rated using a 7-point Likert scale ranging between 1 and 7. The total score of the scale ranges between 13 and 91, with higher scores indicating a higher SOC. A SOC-13 score of 13-63 points corresponds to a low SOC, 64-79 points to a moderate SOC, and 80-91 points to a high SOC [33]. It takes about 6 min to be completed. The tool was translated into Arabic following recommended methods [34]. In details, the questionnaire was translated from English into Arabic by a translator. This was followed by a back-translation to English by another translator. This version was compared with the original English version to identify discrepancies. Then, the two translators made amendments to the Arabic version to produce the final version of the questionnaire.
QOL was assessed using the Kidney Disease Quality of Life-Short Form (KDQOL-SF) [35]. This questionnaire measures symptoms, effect of kidney disease on daily life, disturbance of kidney disease, cognitive functioning, professional status, sexual functioning, quality of social interactions, sleep, social support, and perceived encouragement from the healthcare team and patient satisfaction. These factors are divided into six submodalities: physical functioning, emotional functioning, cognitive functioning, professional functioning, social functioning, and satisfaction with the quality of care. The questionnaire includes 36 items measuring physical and mental health (short form of quality of life questionnaire), 43 kidney disease-targeted items (including two items for patients on peritoneal dialysis which were not considered in the current study), and one overall health rating item, leading to a total of 80 items. Each item was recoded to a 0-100 value, and relevant items were averaged to form each of the different submodalities The KDQOL-SF has well-documented reliability and construct validity for assessing QOL among dialysis patients, as well as a high internal consistency (Cronbach's alpha coefficient = 0.84 to 0.91) [36]. The Arabic validated version of the questionnaire [37] as used, which also shows statistically significant coefficients for reliability tests for all scales of the KDQOL-SF (0.492 to 0.936 for test-retest reliability and 0.337-0.994 for inter-observer reliability) and high internal consistency (Cronbach's alpha coefficient > 0.80). The KDQOL-SF takes about 16 min to be completed.
The Arabic versions of the questionnaires were pilottested on ten Lebanese patients on hemodialysis, the results of which were discarded. One psychologist helped the patients fill out the questionnaires during their stay in the dialysis center.

Statistical analysis
Statistical analysis was conducted using the Statistical Package for Social Sciences (SPSS) version 21. Descriptive analyses were performed to summarize patients' characteristics using means and standard deviation for continuous variables, and frequencies and percentages for categorical ones. The normality of distribution of the variables was confirmed by calculating their skewness and kurtosis; values for asymmetry and kurtosis between − 2 and + 2 were considered acceptable to prove normal univariate distribution [38]. The associations between sociodemographic variables and medical variables, with SOC and QOL were assessed using Independent-Samples T-Test for dichotomous categorical variables, and using Analysis of Variance (ANOVA) and Bonferroni post hoc or Kruskal-Wallis for categorical variables with at least three groups, as applicable. The association between SOC and QOL was first explored using Pearson Correlation, whereby a |r| between |0.90 and 1.00| denoted a very strong correlation, between |0.70 and 0.89| denoted a strong correlation, between |0.40 and 0.69| denoted a moderate correlation, between |0.10 and 0.39| denoted a weak correlation, and between |0.00 and 0.10| denoted a negligible correlation [39]. Then, seven multivariate linear regression analyses, using the Forward method, were used, entering QOL and each of its six submodalities, respectively as a dependent variable, and SOC as independent variable in addition to sociodemographic variables and medical variables with a p-value < 0.2 in the purposeful bivariate analysis [40][41][42][43], as well as variables of clinical or theoretical relevance, irrespective of their significance level in the bivariate analysis [44]. A twotailed p-value < 0.05 was used as an indicator of statistical significance.

Patient consent and ethical approval
Ethical approval was obtained from the Ethical Committee of the Notre Dame des Secours Centre Hospitalier Universitaire. Informed written consent was obtained from each patient before data collection. All the questionnaires were anonymous. The study was conducted according to the Declaration of Helsinki, and the psychology deontological rules were respected throughout the study.

Results
During recruitment period, 196 patients were receiving treatment in the three hospital-based hemodialysis units; among whom, 25 patients were excluded as they were adolescents (n = 3), non-Lebanese (n = 2), receiving hemodialysis for acute kidney injury (n = 4), taking strong medications (n = 8), unconscious (n = 3), have dementia (n = 3), and have hearing problems (n = 2). Out of the 171 eligible patients, 157 consented to participate (response rate: 91.8%) and completed the questionnaires. As shown in Table 1, the average participants' age was 62.1 years, more than half were males (58.6%), the majority were married (75%), unemployed or retired (72.3%), and receiving dialysis treatment for less than 1 year (84.1%). Finally, 5.7% of the sample had an unsuccessful kidney transplantation. and 26.8% were prescribed psychotropic medications.
The SOC and QOL of the study population are detailed in Table 2. The mean QOL score was 51.65 and mean SOC was 48.06.
As shown in Table 3, males, married patients, those with higher education, employed, having hypertension as primary cause of renal failure, and not prescribed psychotropic medications had higher QOL compared with their counterparts. Outpatient visits were weakly negatively correlated with QOL. The association between sociodemographic and medical variables with the submodalities of QOL are also detailed in Table 3.
The results of the correlation between SOC, QOL, and each of its submodalities are detailed in Table 4. SOC was strongly corrected with the total QOL, as well as its physical functioning, emotional functioning, cognitive functioning, and social functioning submodalities. SOC was moderately correlated with professional functioning sub modality of QOL. Nevertheless, it was not correlated with the satisfaction with the quality of care. Table 5 presents the results of the linear regression analyses with QOL and each of its submodalities, expect satisfaction with the quality of care for which the multivariate analysis was not run, given the above-mentioned results. In all analyses, the association between SOC and the independent variable, i.e. QOL and each of its submodalities, remained statistically significant. Specifically, in the model considering QOL as dependent variable, the adjusted R Square of the model was 0.715, meaning that up to 70% of the variance of QOL is accounted for by the model. Accordingly, within this model accounting for potential sociodemographic and medical variables, SOC was highly significantly associated with QOL (unstandardized B = 0.803; standardized B = 0.806; p < 0.001; 95% CI 0.714, 0.893), whereby for a one-unit increase in SOC, a 0.8-unit increase in QOL is expected. Similarly, SOC was highly significantly associated with physical functioning, emotional functioning, professional functioning, cognitive functioning, and social functioning.

Discussion
Through multivariate analyses, this study showed a strong robust association between SOC and QOL and its submodalities, except the satisfaction with the quality of care, in a sample of patients on hemodialysis. Being on disease side of the health-disease continuum, patients receiving hemodialysis are likely to have a low to moderate SOC, given that SOC is initially a predictor of health [45]. This was also the case in our study, considering the low reported mean SOC.
Our finding of a positive association between SOC and physical functioning is also reported in individuals with chronic pain [46] and could be attributed to the role of SOC in modifying the long-term effects of diseases on the functioning of individuals [47]. It is plausible that people who have a high SOC can perceive their resources and consider themselves "good", even if they are in a state of illness [46]. Additionally, these individuals may, as they find meaning in their existence, also find meaning in the physical symptoms and pain they experience, leading to increased functioning.
The SOC is positively associated with emotional functioning. A similar finding was reported in uremic patients, not yet receiving dialysis [25], whereby the stronger the SOC, the less perceived anxiety. Termed as "emotional coherence", the interplay between SOC and emotional functioning positively influences wellbeing [48,49]. Individuals with a high SOC have more resources and the capacity to mobilize these resources to manage their emotions, while a weak SOC is significantly related to greater anxiety-especially somatic anxiety [32]. Also, a low SOC predicts depression [50] and the two concepts have shared characteristics [47,51]. Yet, a high     SOC does preclude depression. While SOC is likely to be stable throughout life, depression may ensue progressively, provided that factors conducive to depression outweigh the impact of SOC.
Our results regarding the positive association between SOC and professional functioning are in line with those of Schnyder et al. [47], where social and emotional dysfunction predicted deterioration of professional functioning. Individuals with a high SOC maintain acceptable functioning after trauma, adversity, or diagnosis compared with individuals with a low SOC [52]. This resides in their ability to take on professional tasks and view them as challenges, not stressors [53], hence finding pleasure in working with stressful demands and showing commitment and involvement in tasks without exhibiting symptoms of burnout [53]. Individuals who contribute at work have a greater capacity to mobilize their general resources of resistance to find a new meaning of their work and carry it on [17]. All of the above explain the recurrent finding in previous research and in our study that, among all the components of SOC, the meaning component is the most associated with professional functioning.
We also found that SOC is positively associated with cognitive functioning. Individuals who seek to adapt to changing conditions must be able to rely on their own ability to plan and solve problems [54]. This requires cognitive and executive functions, whereby an individual with a high SOC is expected to also have a relatively acceptable cognitive functioning.
Similar to the case of emotional functioning, SOC and social functioning are interplayed, whereby social support helps in the development of the SOC [49]. Drageset et al. [55], did not only find a positive correlation between the SOC and social functioning among residents of retirement homes, but also reported SOC as modifying factor in the relationship between social functioning and QOL. SOC was significantly and positively correlated with all the domains of QOL assessed by the Short-Form-36 questionnaire. Nevertheless, social support was positively correlated with healthrelated QOL irrespective of the level of SOC.
Amongst all submodalities of QOL, SOC was only not correlated with the satisfaction with the quality of care. The relationship between the dialysis patient and the healthcare team is unique, as it is continuous and includes issues of dependency, regardless of the internal resources and skills of the patient [56]. In addition, the patient does not perceive the relationship with the healthcare team as a purely therapeutic relationship; it is closer to the primary attachment relationship with the love object which is characterized by absolute dependence, but is now necessary to maintain life. Detachment from the caring body, outside the transplant, means death [57]. To make this debt life, the patient cannot disqualify the healthcare team, but on the contrary, idealizes it. There is an unconscious fear that caregivers would no longer provide care in case the patient gives them comments [58]. Hence, even patients with a weak SOC cannot criticize their healthcare team. Our results are similar to those reported by Langius and Lind [59], who highlight the lack of relationship between the SOC and the coordination or perception of information from the healthcare team among patients with oral and pharyngeal cancer.
The positive association between SOC and QOL have been long reported among chronic patients, such as those with Parkinson's disease, chronic obstructive pulmonary disease, asthma, diabetes, cancer, and chronic heart diseases [51,[60][61][62], and in longitudinal studies, SOC was shown to predict better QOL [63]. Specifically, Delgado [64], found in patients on hemodialysis that a high SOC is associated with a better subjectively measured QOL and all its domains. However, such an association was not observed in acute dialysis patients, who typically do not develop a strong attachment with the medical team and do not feel the need to develop it since their dialysis therapy is of a short term [61].
Finally, besides its positive effect on QOL, SOC appears to protect against mortality. In a large population-based study (n = 20,579), a strong SOC was associated with a 30% reduction in mortality from all causes irrespective of gender, age, and chronic disease prevalence; this can be explained by the health resilience that a high SOC provides. This concept is primarily a tool for coping with stress; the lack of which predicts a high mortality rate [65].

Clinical implications
Based on the findings of this study, it could be suggested that enhancing SOC would likely enhance QOL, opening for important therapeutic implications. especially the communication and interaction between the psychologist in the hospital, the medical team, the hospital, and the patient. It is highly plausible that enhancing SOC would result in a better QOL. Indeed, a recent pretest-post-test control group experimental study among patients on peritoneal dialysis showed that salutogenesis-based care enhances the SOC and self-efficacy, provides symptom control, and decreases dialysis symptoms [26]. Specifically, through support therapy, psychologists are encouraged to listen, encourage, validate, and counsel. This will help the patient understand what he came through and accept that he has the right to have emotions and thoughts, i.e. enhance the comprehension component of the SOC. A psychologist can also target the management component of the SOC by helping the patient to identify their internal and external resources to become aware of their capacities to manage their situation and sustain their efforts, and to find a sense for their experience to realize that they are first and foremost persons, regardless of their diagnosis and illness [66], hereby improving patient's meaning, i.e. the third component of the SOC. These components can also be targeted through other approaches, such as psychodynamic therapy [67] and cognitive behavioral strategies [68][69][70].
The healthcare team can also play a decisive role in the development of a SOC in patients in hospitals and nursing homes for a better QOL. The nursing team should show a constant and sufficient form of care. Furthermore, clear and coherent communication activates understanding among those receiving care. Caregivers can use communication tools to get the message across, such as the "teach-back", ultimately leading to a good understanding [71]. They can also help and encourage the patient to become aware of their resources and to use them routinely in a salutogenic way; hence elevating their sense of management. Likewise, the emotional and social support presented by the nursing body will, in addition to continual motivation, lead to a better meaning of life. A sense of belonging can also be developed, especially in departments where contact is continuous with the nursing staff, such as in the case of hemodialysis [55].
Hospitals are seen as formal resources for patients. Their architecture must consider this role. The availability of resources offered by the hospital architecturally is a factor that helps the patient psychologically [72]. The ergonomic architecture of hospitals that takes into account the needs of the patient can increase the speed of healing by up to 30.8% and decrease mortality by 38% [17]. Enhancing the "functionality" of the care space improves the SOC, specifically control, for the patient and the healthcare team simultaneously. With clear signals and informative papers, the hospital structure can enhance the comprehension of the patient [72]. Even if the hospital is not the ideal place to help the patient find meaning in life, the ergonomics of the environment can be inspiring and can create facilitations to decrease the isolation and the non-productivity of the patients during their hospitalization [72].

Strengths and limitations
This study pioneers in exploring the association between SOC and QOL and its submodalities in the Arab World, specifically Lebanon. This article hence addresses a research priority and contributes to filling the research gap in mental health in the Arab World [73,74]. This study was conducted on a powered sample, using validated and widely used tools in the international literature to assess the variables of interest, namely, the SOC-13 and KDQOL-SF. Furthermore, while the association between SOC and QOL was previously in general assessed using bivariate statistics, we explored this relationship using multivariate statistics accounting for numerous sociodemographic and clinical characteristics.
In contrast, we acknowledge the limitation that some factors associated with QOL among patients on hemodialysis were not included in the present study, such as coping strategies, resilience, religiosity…, and that we opted for self-reported data for a limited number of variables. Also, since a psychologist helped in collecting the data from the patients, this would have introduced some social acceptability bias. Furthermore, given the cross-sectional nature of this research, a cause-and-effect relationship between the SOC and QOL cannot be established. Whilst this study provides evidence on an association between these two variables, and robust interventional studies are needed to establish the hypothesis that enhancing SOC could indeed enhance the QOL of patients on hemodialysis. Moreover, further research is needed to ascertain if SOC is conceptually different from self-efficacy, hope, and resilience. This is an important question to address specifically in this patient-population, especially that, for example, studies have shown that hope is associated with a decreased burden of fluid and dietary restriction in dialysis patients [75] and is associated with a decreased incidence of the decline in physical function [76].
It is worth noting challenges encountered during the execution of this study: collecting information from the patients was challenging, especially since some included questions enhance the awareness of the patients about their daily difficulties, which may be accompanied by an emotional discharge. The processing time was also limited by the fatigue of the patients and their snack time, which must be respected in their case. All of these are well-known challenges when working with patients on hemodialysis, and anticipating them can enhance the data collection process.
Finally, while not recruited in a random manner, our sample resembles the general population of patients treated with hemodialysis in Lebanon [77] in many sociodemographic aspects, such as age and gender distribution, marital status, employment status, as well as clinical aspects such as the use of psychotropic medications and failed kidney transplant, potentially enabling us to generalize our findings to this population. Although the Lebanese society is characterized by its resilience, and familial [78], as well as its social support [79]-all of which are known actors associated with SOC and QOL in chronic patients, we suggest that our findings could be generalizable to other settings. because according to Antonovsky and Saggy [80], there is a "cultural stability" of SOC, and the higher the SOC, the more it mobilizes cultural stability. This concept of cultural stability of SOC is evident in the scientific literature [81,82].